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VITAMIN B12 DEFICIENCY
like folic accid, vitamins b12 is essential for cell division, hence requirement for it increases during pregnancy. animal products are the main source. Unlike. Folic acid,stores in the liver are enough to supply up to two years, needs. Daily requirements are so low (3 ug in pregnant women) that gross dietary deficiency is rare except in southern India where it is seenasa results of low intake by vegetarians with intestinal malabsorption
Malarial anaemia follows repeated faciparum parasitaemia and its features in partially immune and non-immune women are not exactly identical. In the partially immune, the anaemia starts in the second trimester of pregnancy and younger women and primigravidae are more vulnerable then older women and multigravaidae various immune haemolytic processes triggered by Malarial
Parasitaemia act as the principal cause ,with erythrophagocytosis,folic acid deficiency and hypersplenism being aggravating factors. Often the severity of anaemia and the degree of parasitaema do not match. Stained blood films rarely show parasitaemia ,
the parasitised red calls having been destroyed or removing from the circulation. The causal immune mechanism sometimes continue for months after parasitaemia chapter 7 provides further information in non- immune women,
Anaemia can complicate a severe Malarial attack at any stage of pregnancy and there are no party differences. The pathogenesis is also multifactorial acute haemolysis (not necessarily immune- mediated) impaired marrow function and secondary bacterial infection are all involved. The degree of anaemia correlates well with parasitaemia thrombocytopenia is common a useful diagnostic feature is the presence of Malaria pigment in monocytes in Stained blood films.
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